Refractory Pityriasis rubra pilaris treated with Adalimumab: a case report

Pityriasis Rubra Pilaris (PRP) is a rare inflammatory dermatosis, clinically presenting as keratinization disorder, with follicular and palmoplantar hyperkeratosis, in addition to orange-red scaly plaques, accompanied by characteristic islands of healthy skin. Sometimes, conventional treatment proves be ineffective, this work aims present case patient failed first second lines options, responding well adalimumab. Despite all options available, more qualified specific studies are needed establish standardized based on evidence high scientific level, thus raising the degree efficacy therapeutic safety PRP.